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KMID : 0380020070220010030
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 1 p.30 ~ p.36
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AChE Inhibitory Effect and Antioxidative Activity of Submerged Cultured Products from Hericium erinaceum
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Jeong Jae-Hyun
Lee Shin-Young
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Abstract
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The water-soluble or ethanol-soluble materials extracted from fruit bodies and cultured products (mycelium and broth) of H. erinaceum were prepared, and their inhibitory effect on acetylcholinesterase (AChE) activity from Electrophorous electricus was investigated. Inhibition of 75-85% for AChE activity at concentration of 10 mg/ml was obtained and the mechanism was due to general non-competitive inhibition. Especially, the supernatant of culture broth by ethanol treatment, exhibited a strong inhibition activity of 94% at 10 mg/ml. The samples from fruit body, mycelium and broth (supernatant and precipitate by ethanol treatment) which were extracted from H. erinaceum, were very effective to inhibit the initial stage oxidation of a linoleic acid at concentration of 0.1 mg/ml. The antioxidative activity of these samples were superior than rutin, vitamin C and tocopherol as antioxidative standards by FTC (ferric thiocyanate) method, and also showed the very strong antioxidative activity of 95% without significant difference of the samples by TBA-RS (thiobarbituric acid-reactive substance) method.
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KEYWORD
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Hericium erinaceum, mycelium, culture broth, fruitbody, hot water or ethanol extract, AChE inhibition, antioxidative activity
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